Irving Klotz

Irving Klotz received his bachelor of science degree in 1937 and his Ph.D. in 1940, both from the University of Chicago.  He joined the Northwestern faculty in 1940, was awarded tenure in 1947, and retired in 1986.  He passed away on April 27, 2005.

Irving Klotz was a noted expert in chemical thermodynamics and the mechanisms by which small molecules, like drugs, bind to their targets. The fundamental scientific principles and techniques developed by Klotz provided the foundation for current "rational drug design" methods used by pharmceutical researchers worldwide.

In addition to more than 200 scientific articles in peer-reviewed journals, Mr. Klotz was the author of numerous books including “Ligand-Receptor Energetics: A Guide for the Perplexed” and co-author, with Robert M. Rosenberg, of “Chemical Thermodynamics: Basic Theory and Methods.” He also wrote on topics of more general scientific interest. One of his notable books in this area is “Diamond Dealers and Feather Merchants: Tales from the Sciences.”

Klotz's many honors include membership in American Academy of Arts & Sciences in 1968 and the National Academy of Sciences in 1970. He was named a Fellow of the Royal Society of Medicine in 1971.