Third Place - Eitan Israeli

Postdoctoral Fellow, The Ken & Ruth Davee Department of Neurology

"Intermediate Filaments Accumulation in Disease"

Giant Axonal Neuropathy is a rare inherited genetic disease that severely affects the nervous system. Affected nerve cells accumulate an excess of cytoskeletal proteins, which cause the axons (branches of nerve cells) to swell and prevent the cells from functioning properly.

This image shows the abnormal accumulation of the cytoskeletal proteins (stained bright green) in nerve cells, which have been cultured in a lab. The nuclei have been stained blue.

The disease occurs when the body lacks a functional protein whose job it is to break down unwanted cell components. Israeli and his colleagues in the Opal Laboratory aim to uncover why the functional protein is lost and how it can be replaced.

Technique: Confocal fluorescence microscopy

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